Leftover Smoked Brisket Sandwich With Barbecue Sauce

This Smoked Brisket Sandwich takes classic grilled cheese to the next level by simmering tender slices of leftover smoked beef brisket in a tangy BBQ sauce and topping it with gooey, melty cheese. This quick dinner recipe has tons of flavor - sure to become a new family favorite!

If you like this recipe, try my Air Fryer Reuben Sandwich next!

Smoked brisket is one of my favorite things to make for large family gatherings. It's easy to do; the brisket cooks while I spend time with my guests, and my meat thermometer lets me know when the internal temperature is reached.

And one of the best things is the leftovers I can use the next day! I use them to make these BBQ brisket sandwiches, Leftover Brisket Chili, Leftover Brisket Tacos, and Brisket Mac and Cheese. Having slices of leftover brisket in the freezer makes it easy to put a delicious meal on the table on a busy day!

Jump to:

• Why This Recipe Works
• Ingredients & Substitutions
• How To Make Leftover Smoked Brisket Sandwich
• Variations
• Expert Tips
• Serving Suggestions
• Recipe FAQs
• More Recipes You'll Enjoy
• Printable Recipe
• Comments

Why This Recipe Works

• It's one of my favorite ways to use leftover beef brisket.
• It's an easy dinner recipe with just a few simple steps.
• It uses simple ingredients and comes together quickly.
• These BBQ beef brisket sandwiches are great for lunch or dinner.
• Your whole family will love them.

Ingredients & Substitutions

• Leftover Brisket. Thin slices of tender brisket are the star of this recipe. If you have a whole brisket, slice it across the grain. Need to make a brisket? Try my easy brisket recipes: Smoked Brisket on Pellet Grill and Electric Smoker Brisket.
• BBQ sauce. Use homemade barbecue sauce or your favorite barbecue sauce. I used my favorite tangy BBQ sauce - Sweet Baby Ray's.
• Bread. I used multigrain bread, but you could use sourdough bread, thick sandwich bread, Texas toast, brioche bread, or Soft Whole Wheat Bread.
• Cheese. Use cheddar cheese, Havarti cheese, or Gouda.

See the printable recipe card at the bottom of this post for a complete list of ingredients and measurements.

How To Make Leftover Smoked Brisket Sandwich

Step 1: Slice brisket against the grain and place in a frying pan or cast iron pan. Add BBQ sauce and heat over low heat until hot.

Step 2: Slather two slices of bread generously with butter. Heat a frying pan over medium heat. Place one slice of bread butter side down. Spoon the heated brisket slices on top of the bread. Top with cheese and another slice of bread, butter side up.

Step 3: Cook the sandwich until it starts to turn golden brown on the bottom. Flip it over carefully with a spatula and cook the other side until golden brown.

Step 4: Remove from the frying pan, cut in half diagonally, and serve immediately with coleslaw or a simple green salad.

Variations

• Spicy. Add a kick with chopped jalapeno, hot sauce, or red pepper flakes.
• Tangy. Add a splash of apple cider vinegar for a little extra tang.
• Low and Slow. Heat brisket in a slow cooker with BBQ sauce on low for a couple of hours for the tenderest BBQ beef brisket sandwiches.
• Panini. Use a panini press to make the brisket sandwich.
• Loaded. Pile on extra goodies like sautéed mushrooms, crispy bacon, or even a fried egg for a hearty, loaded sandwich that turns into a complete meal.
• Slider. Skip the sliced bread and pile saucy heated brisket on brioche rolls or Homemade Air Buns with crunchy coleslaw and extra sauce for a brisket slider.

Expert Tips

• Heat the sliced brisket and barbecue sauce on low to retain moisture.
• Cover the pan with a lid for a minute or two to ensure the cheese melts perfectly.
• Only heat enough brisket to use in your sandwiches.
• Customize your own sandwiches how you like. If you want extra barbecue sauce, a different type of cheese, or various toppings, go for it!
• Multiply ingredients by how many sandwiches you want to make.

Serving Suggestions

Serve these sandwiches with Air Fryer Green Beans, Old-Fashioned Cucumber Salad With Mayonnaise, Creamy Red Potato Salad, or Greek Cucumber Salad.

Top with Miracle Whip Coleslaw or Canned Cowboy Candy, and serve with a side of Smoked Beans With Bacon and crunchy potato chips. Or check out my collection of the Best Side Dishes to Serve with Smoked Brisket.

Recipe FAQs

More Recipes You'll Enjoy

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Printable Recipe